Integrated blood treatment module having a support element

ABSTRACT

The invention relates to support element ( 4 ) comprising a main body ( 6 ) having a front wall ( 25 ) and a peripheral wall ( 32 ) projecting away from the front wall. The front wall and the peripheral wall define a housing compartment ( 33 ) designed to receive a fluid distribution circuitry cooperating with a treatment unit for defining an integrated blood treatment module.

This is a division of application Ser. No. 10/775,993, filed Feb. 9,2004 now U.S. Pat. No. 7,247,146 and claims the right to priority basedon Italian Patent Application No. MI2003A0213, filed Feb. 7, 2003, andclaims the benefit of U.S. provisional application No. 60/470,453, filedMay 15, 2003, the contents of which are incorporated herein byreference.

BACKGROUND OF THE INVENTION

The present invention relates to a support element, to an integratedblood treatment module comprising said support element and to anextracorporeal blood treatment apparatus equipped with said integratedmodule.

As is known, in order to carry out extracorporeal blood treatments suchas for instance haemodialysis, haemofiltration, haemodiafiltration,plasmapheresis, extracorporeal blood oxygenation, extracorporeal bloodfiltration or other treatments, it is necessary to provide for at leastan extracorporeal circuit through which the blood flows and is conveyedtowards treatment unit; the treated blood is then carried back to thepatient's cardiovascular system. Referring by way of example to adialysis treatment, the extracorporeal circuit used comprises: adialysis filter consisting of a housing body defining at least a firstand a second chamber separated from each other by a semipermeablemembrane, a blood withdrawal line leading to the first chamber of thedialysis filter and a blood return line designed to receive blood comingout of the first chamber and to carry it back to the patient. The secondchamber of the dialysis filter is then connected to a circuit for thecirculation of a dialysis liquid designed to receive the impurities thatare present in the blood and the excess fluid that has to be removedfrom the patient's blood.

Currently, in apparatus for extracorporeal blood treatments all thelines designed for the circulation of the dialysis liquid are housedwithin the dialysis apparatus, whereas the lines constituting theextracorporeal blood circuit are replaced at every treatment andsuitably connected to the dialysis filter, which can be replaced eitherat every treatment or from time to time, as required.

From a structural point of view the dialysis filter, the lines for thecirculation of the dialysis liquid and the lines constituting thewithdrawal and return branch carrying the blood back to the patientconsist of separate parts that are connected and cooperate duringoperation after being suitably assembled.

There are also apparatuses that are available on the market at present,designed in particular for intensive treatment of kidney failure, whichare advantageously equipped with integrated modules comprising a supportstructure, a dialysis filter engaged to the support structure by meansof a suitable support projecting from said structure, as well as ahydraulic circuit comprising the tubes that are necessary to define theblood withdrawal and return lines leading to the patient, the possiblelines for the infusion of anticoagulant or substitution liquids, theintake line for the dialysis liquid and the discharge line for theliquid coming out of the second chamber of the dialyser.

The integrated modules described above enable an easy and immediateassociation of the lines to the treatment apparatus and do not requireany connection between the treatment unit, such as for instance adialysis filter, and the various tubes or lines designed to convey bloodand other fluids. Moreover, said integrated modules enable the removalboth of the tubes conveying the blood and of the tubes conveying otherfluids at the end of the treatment. In other words, thanks to a simpleloading and connecting operation of the terminals and of the fluidconveyance lines to the corresponding sources such as bags or others,the user can install a dialysis apparatus. Analogously, once thetreatment step is over, by simply disconnecting and disassembling theintegrated module from the blood treatment apparatus in few operations,the operator can completely disassemble both the extracorporeal circuitand the blood treatment unit, as well as the tubes for the circulationof possible infusion liquids and of the dialysis liquid. The easyinstallation of said modules ensures an efficiency and a speed that arecertainly advantageous for intensive treatments where the personnel, whomight not be conversant with the use of blood treatment apparatuses, canthus operate rapidly and with a high reliability.

From a structural point of view treatment modules consist of a supportelement to which the fluid distribution circuitry and the bloodtreatment unit are suitably fastened.

The support element can have different shapes and geometries accordingto the type and model of integrated module; in particular, it is knownabout a first arrangement in which the support element is basicallydefined by a quadrangular plate to which respective tube lengths arefastened by means of suitable engagement connectors, and which alsosupports the filter directly in its central portion by means of anauxiliary support structure.

The tubes of the fluid circuitry engaged laterally with respect to thesupport element define suitable tube lengths basically shaped as a U andprojecting away from the respective sides. Said U-shaped tube lengthsare designed to be associated to respective peristaltic pumps forconveying fluids therein.

It is also known about a further embodiment of an integrated module, inwhich a support element is designed to keep basically U-shapedrespective tube lengths in position and carries a filter suitablyengaged thereto.

The support element is defined by a quadrangular frame completely openon two opposite sides and consisting of respective consecutive sideshaving the U-shaped tube lengths, which are housed within said frame.

However, the integrated modules that are present and widely spread todayon the market have proved to be susceptible of several improvements.

In particular, it should be noted how the tube lengths that are designedto cooperate with the respective peristaltic pumps are generally easilyaccessible by the operator.

In other words, especially when the apparatus is working, the variousparts that are moving (generally the peristaltic pumps) are placed inthe front of the apparatus, thus enabling possible unwanted bodies toget near the moving parts by chance and to interfere with the goodworking of said pumps; also the operators can come into unintentionalcontact with the moving pumps.

Furthermore, said support elements have proved to be improvable as faras their constructive geometry is concerned, in order to improve thecentering and the engagement to the front wall of the blood treatmentapparatus; said element, have eventually proved to be susceptible ofchanges also as far as the particular relative arrangement of thevarious components and their overall dimensions and compactness areconcerned.

SUMMARY OF THE INVENTION

The present invention therefore aims at solving basically all thedrawbacks referred to above.

A first aim of the invention is to provide for a support element and acorresponding integrated module with an easier installation, which alsoenable a suitable protection when the machine is working, from and ofthe moving parts of said machine by preventing a direct access to thepumps.

Obviously, the modules according to the invention keep assemblingoperations extremely simple and rapid to be carried out.

A further aim of the invention is to enable an optimal arrangement ofthe tube lengths on the pumps and to ensure an optimal and firmengagement of the module to the machine.

Auxiliary aims of the present invention are then to enable theimplementation of extremely compact integrated modules with such anarrangement of the tube lengths as to minimize the amount of dialysisfluid to be used and to minimize the amount of blood circulating outsidethe patient.

These and other aims, which shall be evident in the course of thepresent description, are basically achieved by a support element, by anintegrated module and by a machine as described in the appended claims.

Further characteristics and advantages will be clearer from the detaileddescription of a preferred though not exclusive embodiment of a supportelement, of an integrated module and of a corresponding machine forextracorporeal blood treatment according to the present invention.

BRIEF DESCRIPTION OF THE DRAWINGS

This description will be given below with reference to the appendeddrawings, which are provided as a mere guidance and are therefore notlimiting, in which:

FIG. 1 shows a schematic view of a hydraulic circuit carried out by anapparatus and a module according to the present invention;

FIG. 2 shows a view from above of a support element according to thepresent invention;

FIG. 3 shows a section of the module of FIG. 2 according to lineIII-III;

FIG. 4 shows a further section of the element of FIG. 2 according toline IV-IV;

FIG. 5 shows again a section according to line V-V of FIG. 2;

FIG. 6 shows a section according to line VI-VI of the support element ofFIG. 2;

FIG. 7 shows a perspective view from a first side of the support elementof FIG. 2;

FIG. 7 a shows an enlarged detail of the element of FIG. 7;

FIG. 8 shows a perspective view from the opposite side of the supportelement of FIG. 7;

FIG. 8 a shows an enlarged detail of the element of FIG. 8;

FIG. 9 shows a perspective view of an integrated module according to thepresent invention;

FIG. 9 a shows an enlarged detail of the module of FIG. 9;

FIG. 10 shows a perspective view from the opposite side of the module ofFIG. 9;

FIG. 10 a shows an enlarged detail of the module of FIG. 10;

FIG. 11 shows the integrated module of FIG. 10 to which a bloodtreatment unit can be associated;

FIG. 12 shows a section of a connector of the support element and of acounter-connector of the blood treatment unit;

FIG. 13 shows a further section of a connector according to the presentinvention;

FIG. 14 shows a schematic view of the integrated module that can beassociated to the machine, equipped with the hydraulic circuitry;

FIG. 15 shows a machine according to the present invention to which anintegrated module can be associated; and

FIG. 16 shows a front view of the machine of FIG. 15 with an integratedmodule without the hydraulic circuitry thereto associated.

DETAILED DESCRIPTION

With reference to the figures mentioned above the numeral 4 globallyrefers to a support element according to the present invention.

Conversely, the numeral 1 refers to an integrated module (combination ofa support element 4, a distribution circuitry 15 and a blood treatmentunit 5) that can be used together with extracorporeal blood treatmentmachines 2 according to the present invention.

As can be inferred from the appended Table 1, the global hydrauliccircuit carried out thanks to the cooperation between the integratedmodule and the machine consists of a blood line or circuit 44, whichtakes blood from a patient, for instance by means of a catheterintroduced into a vein or artery of said patient, and through at least awithdrawal branch or inlet line 46 carries said blood, for instancecontinuously, to a filtration unit 5.

Then the blood passes through a primary chamber of said filtration unit5 and through an outlet line 47 the treated blood is carried back to thepatient.

The connection with an auxiliary pre-infusion line 50 is providedimmediately downstream from the blood collecting zone on the inlet line46.

In particular, the machine is equipped with at least a secondary fluidcontainer or bag 87 for supplying the pre-infusion line 50; by usingcorresponding means for conveying fluid, in the example shown comprisingan auxiliary pre-infusion pump 3 e, for instance a peristaltic pump, itis possible to control the fluid flow within said line by introducingsaid fluid directly into the blood by means of a direct connection tothe inlet line 46.

Generally, the secondary fluid container 87 can house a suitablebiological fluid for a pre-infusion, however said bag 87 can alsocontain an anticoagulant, generally of a topical nature so as to ensurea particular working of the machine as shall be explained below infurther detail.

After defining a direction of blood circulation 88 from the inlet line46 towards the filtration unit and from the latter through the outletline 47 towards the patient, a known blood pressure sensor 89, whichshall not be described in further detail, is placed immediatelydownstream from the auxiliary pre-infusion line 50.

The blood circuit 44 therefore comprises means for conveying fluid, i.e.in this particular case at least a blood pump 3 a for controlling andmanaging the suitable blood flow in the circuit.

Also the blood pump 3 a is generally a peristaltic pump.

Following the direction of blood circulation 88, there is then a device90 for administering an anticoagulant, for instance a syringe containingsuitable doses of heparin.

The blood then passes through another pressure sensor 91 controlling thecorrect flow within the blood circuit.

After passing through a main chamber of the filtration unit 5, where thesuitable exchanges of substances, molecules and fluids occur by means ofa semipermeable membrane, the treated blood enters the outlet line 47first passing through a gas separating device (generally air) 52commonly known as “bubble trap”, designed so as to ensure the removal ofair bubbles present in the blood or introduced into the blood duringtreatment.

The treated blood getting out of the separating device 52 then passesthrough an air bubble sensor 92 verifying the absence of said dangerousformations within the treated blood that has to be re-introduced in thepatient's blood circulation.

Immediately downstream from the bubble sensor 92 there is an element 93which, in case of alarm, can block the blood flow towards the patient.

In particular, should the bubble sensor 92 detect the presence ofanomalies in the blood flow, the apparatus through the element 93 (be ita tap, a clamp or similar) would be able to block immediately thepassage of blood so as to avoid any consequence to the patient.

Downstream from said element 93 the treated blood is then carried backto the patient undergoing therapy.

The extracorporeal blood treatment apparatus shown above is thenequipped with a fluid circuit 94, which is also provided with at leastan inlet line 48 leading into the filtration unit 5 and with an outletline 45 b from the filtration unit.

At least a primary fluid container 95 is designed to supply the inletline 48 of the fluid circuit 94 (generally the primary fluid container95 shall consist of a bag containing a suitable dialyzing liquid).

The inlet line 48 then comprises means for conveying fluid such as aleast a pump 3 c (in the embodiment shown a peristaltic pump) forcontrolling the flow of liquid from the bag 95 and for defining adirection of circulation 96.

Downstream from the pump 3 c in the direction of circulation 96 there isa branching 85 splitting the fluid circuit 94 up into an intake branch76 and into an infusion branch 77.

In particular, the infusion branch 77 is connected to the outlet line 47of the blood circuit 44.

In other words, by means of said infusion branch 77 it is possible toobtain a post-infusion directly in the blood line using the content ofthe primary fluid container 95.

Conversely, the intake branch 76 conveys the fluid directly to thefiltration unit and in particular to a secondary chamber of said unit.

The fluid circuit 94 is further equipped with selecting means 97 fordetermining the percentages of fluid flow within the infusion branch 77and the intake branch 76.

Generally said selecting means 97, usually placed near the branching 85,can be positioned at least between a first operating condition in whichthey allow the passage of fluid in the intake branch 76 and block thepassage in the infusion branch 77, and a second operating condition inwhich they allow the passage of fluid in the infusion branch 77 andblock the passage in the intake branch 76.

In other words, said selecting means 97 can consist of a valve elementoperating on the fluid circuit 94 by alternatively blocking the passageof fluid in either branch.

It is also evident that it might be provided for suitable selectors,which are able to establish a priori the amount of liquid that has topass through both branches simultaneously.

It will also be possible to vary the percentages of fluid in eitherbranch as a function of time and of the pre-established therapies.

The dialysis liquid through the intake branch 76 gets into a secondarychamber of the filtration unit 5.

In particular, the primary chamber through which the blood flow passesis separated from the secondary chamber through which the dialysisliquid passes by means of a semipermeable membrane ensuring the suitablepassage of the dangerous substances/molecules and of fluid from theblood towards the dialysis liquid mainly by means of convection anddiffusion processes, and also ensuring through the same principles thepassage of substances/molecules from the dialyzing liquid towards theblood.

The dialysis fluid then gets into the outlet line 45 and passes througha suitable pressure sensor 98 whose function is to control the workingof said line.

There are then means for conveying fluid, for instance a suction pump 3b controlling the flow in the outlet line 45 within the fluid circuit94.

Also said pump will generally be a peristaltic pump.

The fluid to be eliminated then passes through a blood detector and isconveyed into a collection container or bag 99.

Further analyzing the peculiar circuit of the apparatus according to theinvention, note the presence of at least another infusion line 51 actingon the outlet line 47 of the blood circuit 44.

In particular, the infusion fluid is taken from at least an auxiliarycontainer 200 and is sent directly to the outlet line 47 of the bloodcircuit 44 through means for conveying fluid, generally an infusion pump3 d controlling its flow (in the example a peristaltic pump).

In particular and as, can be observed in the appended figure, theinfusion liquid can be introduced directly into the gas separatingdevice 52.

As can also be inferred, the infusion branch 77 of the fluid circuit 94and the infusion line 51 are equipped with a common end length 201letting into the blood circuit 44.

Said intake end length 201 is placed downstream from the infusion pump 3d with respect to a direction of infusion 202 and carries the fluiddirectly into the bubble trap device 52.

Further referring to the diagram in FIG. 1, note the presence within theinfusion line 51 of at least a pre-infusion branch 79 connected to theinlet line 46 of the blood circuit 44.

In further detail, downstream from the infusion pump 3 d with respect tothe direction of infusion 202, there is a branching 86 splitting theinfusion line 51 up into pre-infusion branch 79 and post-infusion branch80.

The pre-infusion branch 79, in particular, carries the fluid taken fromthe bag 200 on the inlet line 46 of the blood circuit downstream fromthe blood pump 3 a with respect to the direction of circulation 88.

Conversely, the post-infusion branch 80 is connected directly to thecommon end length 201.

The infusion line 51 further comprises selecting means 203 fordetermining the percentage of liquid flow to be sent to thepost-infusion branch 80 and to the pre-infusion branch 79.

The selecting means 203 placed near the branching 86 can be positionedbetween at least a first operating condition in which they allow thepassage of fluid in the pre-infusion branch 79 and block the passage inthe post-infusion branch 80, and at least a second operating conditionin which they allow the passage of fluid in the post-infusion branch 80and block the passage in the pre-infusion branch 79.

Obviously, as in the case of the selecting means 97 present on the fluidcircuit 94, also the other selecting means 203 will be able to determinethe percentage of fluid that has to pass in each of the two branches andto possibly vary it in time in accordance with the planned therapies.Moreover, the selecting means 97 and the other selecting means 203 willgenerally though not necessarily be of the same nature.

The apparatus is then equipped with means 204 for determining at leastthe weight of the primary fluid container 95 and/or of the auxiliaryfluid container 200 and/or of the secondary fluid container 87 and/or ofthe collection container 99.

In particular, said means 204 comprise weight sensors, for instancerespective scales 205, 206, 207, 208 (at least an independent one foreach fluid bag associated to the apparatus).

In particular, there will be at least four of said scales, each onebeing independent from the other and measuring the respective weight ofa bag.

It should then be pointed out that there is a processing unit or CPU 209acting on the blood circuit 44 and in particular on the pressure sensor89, on the blood pump 3 a, on the device 90 for heparin infusion, on theother pressure sensor 91, and on the device for detecting the presenceof air bubbles 92 and on its respective closing element 93.

Said CPU 209 has also to control the fluid circuit 94 and, inparticular, shall be input with the data detected by the scales 205 andconcerning the weight of the bag 95 and shall act on the pump 3 c, onthe selecting means 97, on the pressure sensor 98, then on the suctionpump 3 b and shall eventually receive the data detected by the scales208 whose function is to determine the weight of the collectioncontainer 99.

The CPU 209 shall also act on the infusion line 51 checking the weightof the auxiliary container 200 (checked by the scales 206) and will beable to control both the infusion pump 3 d and the other selecting means203.

Eventually, the CPU 209 shall also act on the auxiliary pre-infusionline 50 detecting the weight of the secondary fluid container 87 bymeans of the scales 207 and suitably controlling the pump 3 e accordingto the treatments to be carried out.

Reminding that the above description has been made with the sole purposeof describing the whole of the hydraulic circuit of the extracorporealblood treatment apparatus, here is a short description of the working ofthe device.

Once the whole hydraulic circuit and the filtering unit 5 have beencorrectly associated to the apparatus so that the various peristalticpumps engage the respective lengths of tubes and that all the sensorshave been suitably positioned, and the various bags containing thevarious fluids have been associated to the corresponding liquidintake/suction lines, and the blood circuit has been connected to apatient's artery/vein, the initial circulation of blood within itscircuit is enabled.

Therefore, according to the kind of therapy that has been set, theextracorporeal blood treatment apparatus is automatically started andcontrolled by the processing unit 209.

If the patient undergoes an ultrafiltration treatment, beyond the bloodcircuit the suction pump 3 b connected to the outlet line of the fluidcircuit 94 is started, so as to take by convection through thefiltration unit a fluid excess in the patient (beyond the dangeroussubstances/molecules).

Conversely, if the therapy that has been set comprises a haemofiltrationtreatment, beyond the blood circuit and the suction pump 3 b for takingfluids by convection also the pump 3 c on the inlet line of the fluidcircuit 94 and the selecting means 97 placed so as to enable apost-infusion are started.

Also the infusion line 51 shall be used so as to enable a furtheraddition of liquids to the post-infusion or to enable a suitablepre-infusion.

Conversely, if the treatment involves haemodialysis, the pumps 3 c and 3b of the fluid circuit 94 shall be started and the selecting means 97shall be positioned so as to ensure the passage of the dialysis liquidonly towards the filtration unit 5 so as to take substances and/ormolecules and/or liquids by diffusion and possibly by convection if thetransmembrane pressure through the filtration unit is other than zero.

Eventually, if a haemodiafiltration treatment has to be carried out,beyond the blood circuit the fluid circuit and therefore the pumps 3 cand 3 b shall be started, so as to ensure a circulation of the liquidwithin the filtration unit 5 and also the pump 3 d of the infusion line51 shall be started so as to ensure a pre- or post-infusion.

Obviously, it will be possible to set up different therapies comprisingone or more of the treatments referred to above.

In all the treatments described above, possibly except theultrafiltration treatment, it will be possible to use the auxiliarypre-infusion line for introducing an anticoagulant and/or a suitableinfusion liquid into the blood.

Obviously, the anticoagulant can also be administered by means of thesuitable device 90 designed for the introduction of heparin into blood.

Concerning this it should be pointed out that the machine according tothe invention is designed to receive various kinds of syringes accordingto the amount of anticoagulant to be administered.

Obviously, it is the control unit 209 that, being connected to thevarious devices, sensors, pumps and being input with the data on weightfrom the various scales, is able—once it is set—to control and automatethe whole working of the apparatus.

In further detail, it is possible to set the flows of the various pumpspresent on the machine in accordance with the therapy or therapies to bestarted. Obviously, the suitable setting of said flows results in anamount of fluid taken from the patient (weight loss), which willgenerally be given by the difference between the weight of the liquidthat has been collected in the bag 99 and of the liquid circulated inthe circuit through the primary fluid container 95, the auxiliary fluidcontainer 200 and the secondary fluid container 87.

In particular, in accordance with the data received by the control unitcoming from the various scales (and the theoretical flow rates fixed oneach pump of therapy/treatment carried out) the control unit 209 shallcontrol the means for circulating fluid in the various lines by suitablyvarying the thrust exerted by the various pumps 3 a, 3 b, 3 c, 3 d, 3 e.

In particular, the signals coming from the scales referred to above 205,206, 207, 208 are used by the control unit 209 for determining theweight of the particular fluid introduced into the line or collected.

In order to determine the amount of fluid released or collected in aparticular bag or container the control unit 209 compares at regularintervals (the greater the flows the smaller the intervals) the actualweight of the container with the desired weight (which is a directfunction of the desired flow for each pump and of the time intervalbetween each control step ΔW=Q Δt).

The desired weight can be calculated as a function of the required flow(stored in a suitable storage unit of the computer) and of the timeelapsed from the beginning of the treatment.

If the actual weight and the desired weight differ from each other, thecontrol unit acts on the corresponding pump so as to reduce, andpossibly cancel, said difference. In other words, during each cycle notan absolute weight variation, but only the variation in the timeinterval is taken into consideration to correct the latter.

The control unit takes into consideration variations in the differencestarting from the last comparison, so as to avoid oscillations of theactual flow around the desired flow.

After the above description of the hydraulic circuit and of the possibleworking of the apparatus according to the invention incorporating saidcircuit, here is shown a detailed structure of the support element 4according to the invention.

The support element as shown in the FIGS. 2 to 8 a generally consists ofa main body 6 and of a support structure 64 associated to said main body6 and placed laterally with respect to the latter.

The main body 6 has a front wall 25 which is generally, though notnecessarily, plane; then there is at least a peripheral wall 32projecting away from the front wall 25 so as to define with the latter ahousing compartment 33 designed to receive at least a portion of a fluiddistribution circuit 15 to be associated to said support element.

As can be seen from FIG. 2, the front wall 25 is delimited by a givennumber of sides 53, 54, 55 and 56, and the peripheral wall 32 projectsaway from each of said sides.

It should be noted that the sides referred to above are basicallyrectilinear and, generally, at least first sides 55, 56 and at leastsecond sides 53, 54 can be identified, which are basically parallel andfacing each other.

In other words, in a view from above the support element 4 has anapproximately quadrangular shape and its front wall 25 is delimited byfirst opposite longer sides 55, 56 with a basically rectilineardevelopment and having each two curved portions 55 a, 55 b; 56 a, 56 bwhose cavities face their respective opposite side.

In further detail each of said curved portions 55 a, 55 b; 56 a, 56 bcan be defined by an arc of circle.

Then there are second opposite shorter sides 53, 54, whose developmentis again basically rectilinear; at least one of said second sides 53, 54has a curved portion 53 a placed between two rectilinear lengths 53 b,53 c, which has in its turn a cavity facing the opposite side.

Here again the curved portion 53 a can be defined by an arc of circle.

As can be further noted by simply observing FIG. 2, the arc of circledefining the curved portion 53 a has a greater radius of curvature thanthe curved portions 55 a, 55 b, 56 a, 56 b defined on the first oppositelonger sides 55, 56, as shall be better explained later.

Examining now the peripheral wall 32 (see FIGS. 7 and 8), it can benoted that it has at least a portion projecting away from each of thesides of the support element 4.

Generally, there will be at least one portion projecting from the firstopposite sides 55, 56, and one projecting away from each of the secondopposite sides 53, 54.

It is also evident that the peripheral wall 32 can also bediscontinuous, i.e. it can have cavities or interruptions provided thatit globally enables to define the aforesaid housing compartment 33.

The embodiment shown in FIGS. 7 and 8 is characterized in that theperipheral wall 32 projects away from all the sides of the front wall 25and defines a basically continuous surface delimiting the housingcompartment 33.

In other words, the housing compartment 33 has an access opening 57without any kind of closing wall, which access opening is designed toface—when the support element 4 is being used—the extracorporeal bloodtreatment machine 2.

Moreover, from FIGS. 3, 4, 5 it can be inferred how sections accordingto a plane transversal with respect to the front surface, and inparticular sections according to planes orthogonal to said front surface25, show that the main body has a substantially C-shaped profile.

The peripheral wall 32 defines the two end lengths of said C, whereasthe front wall 25 defines the elongated length between said two lengths.

It should be noted how the front wall 25 and the peripheral wall 32define a main body 6 having a box-shaped structure basically closed onfive out of its six faces.

Said arrangement results in that, however sectioning the support element4 according to two planes orthogonal one to the other and transversal tothe front surface 25, the main body 6 will have C-shaped sections thatare also orthogonal one to the other.

See in particular for instance the sections of FIGS. 3 and 4.

In still other words, the support element 4 comprises a front wall 25which is able to connect opposite peripheral walls projecting in abasically perpendicular direction from said front wall 25.

As shown in FIGS. 2, 7 and 8, the front wall 25 has a given number ofthrough openings 58 putting into communication the housing compartment33 with the outside environment while the support element is being used.

Referring in particular to the figures described above, it can be notedthat there is at least an opening 58 on each of the curved portions 53a, 55 a, 55 b, 56 a and 56 b and that said openings are defined byconcentric round holes placed on the same axis as the respective arcs ofcircle defining the curved portions.

As far as the materials used are concerned, it should only be pointedout that the main body will be made of a stiff material, plastic forinstance, which can protect the various tube lengths and/or elementstherein contained.

It is also possible to carry out the whole support element or only apart of it with a material that is also transparent so as to obtain avisual access to the housing compartment 33.

Going into deeper structural details and referring in particular to FIG.7, it can be noted that there are several engagement connectors fastenedto the respective sides of the box-shaped body.

In particular, there are at least a first and a second engagementconnector 59 a, 59 b placed laterally with respect to the curvilinearlength 53 a of one of said second sides 53.

Said connectors shall be secured and generally carried out as one piecewith said rectilinear lengths 53 b and 53 c.

There are also pairs of engagement connectors 60 a, 60 b, 61 a, 61 b, 62a, 62 b, 63 a, 63 b respectively engaged near each of the curvedportions 55 a, 55 b, 56 a, 56 b of the first longer sides 55, 56.

In other words, there will be two of said connectors placed exactly onopposite ends of each of the curved portions.

As in the case of the previous connectors, also the engagementconnectors 60 a, 60 b, 61 a, 61 b, 62 a, 62 b, 63 a, 63 b are carriedout as one piece with the main body 6.

Furthermore, all the aforesaid connectors are fastened to the peripheralwall 32, for instance on a free edge of said peripheral wall.

As can be seen in the section of FIG. 5, each engagement connectordefines a gap leading towards the housing compartment 33.

Referring now to FIGS. 7 a and 8 a, it can be noted how the supportstructure 64 associated to the main body 6 is positioned laterally withrespect to the latter.

Also the support structure 64 is stiffly secured to the main body andwill generally be carried out as one piece with the latter.

It should be pointed out that the support structure 64 is engaged to themain body 6 on one of the first longer sides 55, 56 and, in furtherdetail, on the curved portions 55 a, 55 b of said fist longer side 55.

The support structure 64 is equipped with a positioning fin 65 (seeagain FIGS. 7 a, 8 a and the section of FIG. 6), which has a givennumber of main seats 66 a, 66 b, 66 c, 66 d, 66 e suitably placed sothat respective tubes of the fluid distribution circuit 15 associated tothe support element 4 can be engaged therein.

Referring to the relative position of the various components of thesupport structure 64, it can be noted how at least two, and generallythree of said main seats 66 a, 66 c, 66 d are placed on their respectiveengagement connector 60 a, 60 b, 61 a located near the curved portions55 a, 55 b of one of the first longer sides 55.

In other words, the three main seats 66 a, 66 c, 66 d and theirrespective connectors 60 a, 60 b, 61 a are positioned so as to receiveparallel tube lengths (see to this FIGS. 9 and 9 a).

Going back to FIG. 6 and to FIGS. 7 a and 8 a, it can be noted how thepositioning fin 65 comprises two further main seats 66 b and 66 e andhow also the support structure 64 is equipped with two auxiliaryportions 67 and 68, each of them being provided with a respectiveauxiliary seat 67 a, 68 a so that the latter can cooperate with oneanother thus enabling the positioning of tube lengths parallel one tothe other and generally parallel to those present on the three mainseats and on the three engagement connectors referred to above (seeagain FIGS. 9 and 9 a).

The support structure 64 then comprises at least a first covering wall69 lying on a plane parallel to the plane of the front wall 25 so as tocover at least two parallel tube lengths in operating conditions inwhich the support element is engaged to the machine.

Compare to this FIGS. 9 and 16.

In a wholly specular way the support structure 64 comprises at least asecond covering wall 70 lying again on a plane parallel to the plane ofthe front wall 25 so as to cover at least two further parallel tubelengths when the support element is again in operating conditions.

Referring to FIG. 8 it should then be pointed out that the supportelement 64 has a smaller height than—or at the most the same heightas—the peripheral wall 32 of the main body.

This means that the support structure 64 has been designed so as not toincrease the height of the whole support element.

Referring now to FIG. 7, further note at least one and in generally twopositioning projections 72 and 73 associated to the main body 6 anddesigned to enable the correct positioning of a tube length to beassociated to the support element as shall be better explained later(see anyway FIGS. 9 and 14).

Said first and second positioning projections 72, 73 are placed insidethe housing compartment 33 and are generally associated (or also carriedout as one piece) to the front wall 25.

It should then be noted that the support element 4 comprises a main body6 having at least a first and a second connector 7 and 8, spaced awayfrom each other, in which corresponding counter-connectors 9 and 10 ofthe treatment unit 5 (see FIG. 11) are engaged.

The blood treatment unit 5 can for instance be a plasma filter, ahaemodialysis filter, a haemofiltration filter, a haemodiafiltrationfilter or another type of unit.

The first and second connector 7 and 8 are directly engaged to the mainbody 6; in the examples shown said connectors are made of stiff plasticmaterial and as one piece with the main body.

The support element 4 has a third connector 11 spaced away from theconnectors 7 and 8 and engaged directly to the main body 6; in theexamples shown also the third connector is made of stiff plasticmaterial and as one piece with the main body; said three connectorsdefine pairs of connectors having a differentiated central axis one withrespect to the other for the engagement of corresponding pairs ofcounter-connectors associated to different blood treatment units thatcan be mounted onto the support element.

Thus, one main body 6 can be used to carry out integrated modules withdifferent features, thanks to the possibility of engaging treatmentunits 5 not only with different membranes but also with different globalsize and therefore with different distance between central axis of thecorresponding counter-connectors.

Each of the connectors 7, 8, 11 referred to is a stiff support anddefines a fluid passage having a first end portion 12, designed to beput into fluid communication with a corresponding channel 13 present inthe respective counter-connector 9, 10 housed in the treatment unit 5(see also the sections of FIGS. 12 and 13); each connector 7, 8, 11 alsohas a second end portion 14, designed to be put into fluid communicationwith a fluid distribution circuit 15 to be associated to the main body6.

Going into further structural detail, each of said connectors 7, 8, 11comprises a tubular channel 16 defining said first portion, a sealingcollar 17 placed radially outside the tubular channel, and a connectionwall 18 developing without interruptions between an outer side surface19 of the tubular channel and an inner side surface 20 of said collar.

In practice, the outer side surface of the tubular channel, the innerside surface of the sealing collar and the connection wall define aring-shaped engagement seat 21, whose bottom is delimited by theconnection wall, shaped so that a corresponding counter-connector of thetreatment unit can be engaged therein.

The tubular channel 16 is arranged coaxially with respect to the sealingcollar 17, and both turn around a common symmetry axis.

The ring-shaped seat 21 has an increasing radial size getting away fromthe bottom wall and comprises a first zone 22 near the bottom, having aconstant radial size, a second zone 23, distal with respect to thebottom and with a constant radial size greater than the radial size ofthe first zone, and a third zone 24 between the first and the secondzone, having a progressively increasing size getting away from thebottom wall 18.

The tubular channel and the sealing collar of each connector 7, 8, 11project parallel one to the other from the main body 6, so as to defineone direction of coupling with the corresponding counter-connectors of atreatment unit 5.

In the examples of embodiment shown the various connectors have asymmetry axis that is basically orthogonal with respect to a frontsurface 25 of the support element 4.

The support element shown also comprises a fourth connector 26 spacedaway from said first, second and third connector; the fourth connectoris also connected directly to the support element. In the example shownthe fourth connector is made of stiff plastic material and as one piecewith the main body 6 and defines with at least one of the otherconnectors a further pair of connectors associated to a blood treatmentunit to be mounted onto the support element.

The fourth connector comprises a central cylindrical positioning body27, a sealing collar 28 placed radially outside the cylindrical body,and a connection or bottom wall 29 developing without interruptionsbetween an outer side surface 30 of the cylindrical body and an innerside surface 31 of said collar.

In practice, said fourth connector defines an engagement andflow-closing body for a counter-connector of the treatment unit 5.

As shown in FIGS. 11, 12 and 13, the various connectors are made ofstiff material so as to define a mechanical support of the treatmentunit and, if needed, so as to define a passage or a blocking member forthe fluid getting through the counter-connectors 9, 10.

The four connectors that are present in the support element are alignedone with respect to the other and arranged on one side of said mainbody.

More to the point, the main body of the element shown defines theaforesaid housing compartment 33, which can house at least a portion ofthe fluid distribution circuit 15 designed to be associated to thesupport element 4.

The housing seat has an open side 57 ensuring a suitable fitting andpositioning of the integrated module 1 onto the machine 2, as shall bedisclosed later in further detail.

The support element then has an auxiliary structure 35 extendinglaterally and outside with respect to the operating seat from a basezone 36 of the peripheral wall 32.

The four connectors come out from the auxiliary structure: the first,second and fourth connectors 7, 8, 26 are placed one beside the otherand are arranged on a first end zone 37 of the auxiliary structure,whereas the third connector 11 is placed on a second end zone 38 placedopposite the first one.

A support element according to the invention can be suitably used forcarrying out an integrated module, such as for instance the one shown inFIGS. 9-11, in which the support element of FIGS. 2-8 is used by way ofexample.

As can be seen, the treatment unit 5 is fastened to the support element4 on at least the pair of connectors; the treatment unit comprises ahousing body 40, at least a semipermeable membrane 41 (for instance withparallel hollow fibers or with plates) operating inside the housing bodyand defining a first chamber and a second chamber; a first and a secondcounter-connector are associated to the housing body and secured totheir respective connectors housed by the main body 6 (see for instanceFIG. 11).

The first and second counter-connector 9, 10 have a tubular shape andare put into fluid communication with the second chamber of thetreatment unit and with respective end portions 12 of said connectors.

The treatment unit then has an access door 42 leading to the firstchamber, and at least an exit door 43 from said first chamber, for theconnection with an extracorporeal circulation line 44 for blood oranother physiological fluid.

A fluid distribution circuit 15 is engaged to the support element 4 andcooperates with the treatment unit 5.

In further detail said circuit comprises the aforesaid blood line 44,which is fastened to the support element 4 on one of the second sides53, 54 and has the curved portion 53 a.

The blood line 44 is secured to the support element so as to define atleast a tube length basically arranged as a U 44 a with respect to saidsupport element.

Said arrangement is related to the fact of enabling the cooperationbetween said tube length 44 a and a respective pump 3 a while assemblingthe integrated module onto the machine 2.

As can then be inferred from the appended figures, the U-shaped tubelength 44 extends inside with respect to the peripheral wall 32 of thesupport element 4.

The positioning projections 72, 73 previously described act on theU-shaped tube length 44 a so as to keep its correct position.

As can be inferred from FIGS. 1 and 9, the length 44 a of the blood line44 secured to the support element is defined by the withdrawal branch46.

The distribution circuit 15 then has the aforesaid inlet line 48supplying fresh dialysis liquid.

Said line is fastened to the support element on one of the first longeropposite sides 55, 56, as can be seen in FIGS. 9, 9 a, 10 and 10 a.

Also the inlet line 48 is secured to the support element so as to defineat least a tube length basically arranged as a U 48 a with respect tosaid support element.

Also the tube length 48 is designed to cooperate with a respective pump3 c and is placed inside with respect to the peripheral wall 32 of thesupport element.

Referring to FIG. 9 a it can be noted how the inlet line 48 is fastenedto the main body 6 on the support structure 64, and how at least aninlet length 74 of the intake line 48 is engaged into a main seat 66 cof the positioning fin 65, as well as to the respective engagementconnector 60 b.

Analogously, at least an outlet length 75 of the intake line is engagedinto a main seat 66 a of the positioning fin 65 and to the respectiveengagement connector 60 a.

When engaged, the respective connectors and inlet and outlet lengths 74and 75 are placed in a rectilinear arrangement and are parallel one tothe other (see FIG. 9 a).

As can further be seen (see in particular FIG. 10 a), the outlet length75 has a branching 85 splitting up into intake branch 76 conveying thefluid to the blood treatment unit 5, and into infusion branch 77conveying the fluid into the blood line 44.

Said branching 85 is defined on the engagement connector 60 a having a Tshape with an inlet and two outlets.

Also the infusion branch 77 is secured to a main seat 66 b and to anauxiliary seat 77 a.

The infusion branch 77 and the intake branch 76, when engaged to thesupport structure 64, are placed in a rectilinear arrangement and areparallel one to the other.

The fluid distribution circuitry 15 then comprises at least the infusionline 51, which is also fastened on one of the first longer oppositesides 55, 56.

Said infusion line defines a tube length arranged as a “U” 51 a withrespect to said support element 4, so as to be able to cooperate, whenin use, with a respective pump 3 d.

Also the U-shaped tube length 51 a extends inside with respect to theperipheral wall 32 of the support element.

Also the infusion line is secured on the support structure 64 and atleast an outlet length 78 of the infusion line 71 is engaged into a mainseat 66 d of the positioning fin 65 and to its respective engagementconnector 61 a as shown in the appended figures.

In a wholly specular way to the intake line, the outlet length 78 has abranching 86 splitting up into pre-infusion branch 79 conveying thefluid to a withdrawal branch 46 of the blood line 44, and intopost-infusion branch 80 conveying the fluid to a blood return branch 47of the blood line 44.

Here again there is an engagement connector 61 a having a T shape sothat the branching 86 into pre-fusion branch 79 and into post-infusionbranch 80 is defined exactly by said connector.

The pre-infusion branch 79 is then fastened to an auxiliary seat 68 aand to a further main seat 66 e of the positioning fin 65.

When engaged to the support structure, said two branches 79 and 80 areplaced in a rectilinear arrangement and are parallel to one another.

The fluid distribution circuit 15 then has the discharge line 45 securedto the support element also on one of said first longer sides 55, 56.

Said discharge line 55 defines at least a tube length arranged as a U 45a with respect to the support element, which tube length is alsodesigned to cooperate with a respective pump 3 b and extends inside withrespect to the peripheral wall 32 of the support element.

The discharge line 45 is secured to the main body 6 on an opposite sidewith respect to the support structure 64 and the respective inlet length81 and outlet length 82 are engaged into corresponding engagementconnectors 62 b, 62 a.

Eventually, the distribution circuit 15 has the auxiliary pre-infusionline 50.

The latter is fastened to the support element 4 on one of said firstlonger sides 55, 56 so as to define at least a further tube lengtharranged as a U 50 a with respect to said support element.

Also the tube length 50 a is designed to cooperate, when in use, with arespective pump 3 e and extends inside with respect to the peripheralwall 32 of the support element.

In other words, the housing compartment 33 is designed to house allU-shaped tube lengths of the various lines of the distribution circuitry15.

The auxiliary pre-infusion line 50 is secured to the main body on anopposite side with respect to the support structure 64 and therespective inlet length 83 and outlet length 84 are engaged toengagement connectors 63 b, 63 a.

It should then be pointed out that the particular shape of theperipheral wall 32 of the support element 4 defining the arched portionsand the peculiar position of the engagement connectors of the varioustubes result in that the length of every free U-shaped tube portion 44a, 45 a, 48 a, 50 a, 51 a is smaller than or the same as πR+2R, where Ris the radius of curvature of the tube length.

The peculiar shape of the integrated module is such that the freelengths within the housing compartment 33 are as short as possible inaccordance with the radial sizes of the respective pumps which have togenerate the flow within said tubes.

It should then be noted how the U-shaped tube length 44 a of the bloodline is longer than the tube lengths 45 a, 48 a, 50 a, 51 a defined bythe further fluid lines having indeed a longer radius of curvature.

Moreover, the tube length of the blood line can be carried out, ifneeded, with materials differing from those of other tubes and/or it canhave sections for the passage of fluid differing from the other tubes.

From the point of view of the geometrical position of the various tubelengths on the support element note the following.

First of all, the support element can be ideally divided into a firstzone 274 secured to the portion of the blood line 44 which, in operatingconditions of the module 1 engaged to the machine 2, shall be defined bythe lower zone of said module.

Therefore, there will be a second zone 275 opposite the first zone, towhich all the further fluid lines 45, 48, 50 and 51 are secured.

Said second zone consists in its turn of at least two ideal half-partsplaced side by side 275 a, 275 b.

The tube length 45 a of the discharge line 45 and the tube length 50 aof the auxiliary pre-infusion line 50 will be fastened to the secondhalf-part 275 b.

Conversely, the tube length 48 of the intake line and the tube length 51a of the infusion line are fastened to the first half-part 275 a. Saidsplitting into first and second zone 274, 275 and the two half-parts 275a, 275 b of the second zone have been ideally shown in FIG. 9 by meansof hatched lines.

As can be noted, the first and second half-part 275 a, 275 b of thesecond zone 275 are reciprocally placed side by side and generallyspecularly symmetrical to a longitudinal axis of the main body 6.

Should the first zone 274 be geometrically delimited, it could bedefined as the area limited by at least one of the second sides 53(having the curved portion and to which the blood line is secured) andby about half the length of the first opposite longer sides 55 and 56near the second side 53.

Analogously, the second zone 275 is partly delimited by one of saidsecond sides 54 which has no curve and by a portion of the firstopposite longer sides 55 and 56 near said second side 54.

The assembly process of an integrated fluid treatment module comprisesthe stage of installation of a support element 4, for instance as shownin FIGS. 2-8, and of a treatment unit 5 to be coupled to the supportelement.

Then the blood treatment unit is fastened to the support element.

Eventually, a fluid distribution circuit 15 is associated to the supportelement and to the treatment unit so as to create the necessary linesfor blood circulation, discharge, infusion of possible substitutionliquids, dialysis.

Note that the connection of the distribution circuit to the treatmentunit can be before, simultaneous to or follow the stage in which thecircuitry is fastened to the support element.

The stage in which the treatment unit is fastened to the support elementcomprises sub-stages in which a pair of connectors to which thecounter-connectors 9, 10 housed by the blood treatment unit are to befastened are chosen, in which a given amount of glue, normally based ona polymer resin, is placed in the ring-shaped seats 21 of each connectorchosen, in which each counter-connector is at least partially fittedinto its respective ring-shaped seat so as to obtain a mechanicalblocking and a liquid-sealing coupling.

Note that during said fitting stage at least a portion of the glueplaced in the ring-shaped seat reaches the second zone 23 of saidring-shaped seat.

At the end of said stage in which the counter-connector is fitted intoits respective ring-shaped seat, the volume of glue previously placedplus the volume of the portion of counter-connector housed within thering-shaped seat is smaller than the total volume of said ring-shapedseat. It is thus avoided that glue migrates towards the tubular channel16 causing its partial or total occlusion.

The stage in which a fluid distribution circuit 15 is associated to thesupport element 4 and to the treatment unit 5 comprises in its turn thesub-stages in which an end portion of a discharge line 45 for a wastefluid is fastened fluid-sealingly with the second end portion 14 of oneof said connectors, and in which an end portion of an intake line 48 forfresh dialysis liquid is fastened sealingly with the second end portionof another of said connectors.

Said stage of association of the distribution circuit also comprises thesealing fastening of an end portion of a blood withdrawal branch 46 withthe inlet door to the first chamber, and an end portion of a bloodreturn line 47 with the exit door from said first chamber.

The fastening of the various end portions referred to above can takeplace by gluing, by forcing or by hot coupling.

Granted the above, it should be noted that the integrated moduleaccording to the present invention is designed to be used on anextracorporeal blood treatment machine 2 as shown in FIGS. 15 and 16.

In particular, said machine 2 comprises a body 100 provided on its frontsurface 101 with a given number of peristaltic pumps 3 a, 3 b, 3 c, 3 d,3 e designed to cooperate, when in use, with the respective U-shapedtube lengths defined on the integrated module.

As can be noted from FIG. 15, the machine body 11 has a guiding andpositioning projection 102 protruding from the surface 101, which isexactly counter-shaped to the peripheral wall 32 of the support elementto which it should be coupled.

In other words, the guiding and positioning projection 102 has a sidesurface 103 which, when engaged to the integrated module, is delimitedby the peripheral wall 32.

Also the peristaltic pumps protrude from the surface 101 of the machinebody 100 and at least a part of their side surface is counter-shaped tothe peripheral wall 32 of the support element.

In particular, it is exactly the curved portions defined by the curvedlengths of the front wall 25 which are designed to couple with theprotruding side portions of the pumps 3.

The protruding peristaltic pumps and the guiding and positioningprojection 102 define together suitable seats 104 a, 104 b, 104 c, 104 dand 104 e taking a basically semicircular or U shape and designed toreceive the corresponding U-shaped tube lengths 44 a, 45 a, 48 a, 50 a,51 a.

Analogously to what has been described for the integrated module 1, alsoon the front wall of the machine a given number of zones can be defined,and in particular two zones 174, 175 in which the first zone 174comprises the blood pump 3 a, whereas the second counterposed zonecomprises the other pumps 3 b, 3 c, 3 d and 3 e.

The second zone 175 comprises at least two half-parts placed side byside 175 a, 175 b; the intake pump 3 c and the infusion pump 3 d areplaced in said first half-part whereas the auxiliary pre-infusion pump 3e and the suction pump 3 b are placed in the second half-part.

Here again the first and second half-part are specularly symmetrical andplaced side by side on the front wall of the machine and above the firstzone 174.

Eventually, it should be noted that there is at least a first movingelement 105 and a second moving element 106 that are substantiallyidentical and housed directly by the machine body; the latter aredesigned to act respectively on the infusion branch 77 and/or on theintake branch 76 (the first moving element), and on the pre-infusionbranch 79 and/or on the post-infusion branch 80 (the second movingelement 106). In particular, the selecting means 97 and 203 previouslydescribed can comprise said moving elements 105, 106 designed to becontrolled by the CPU 209 so as to selectively determine the blocking orpassage of fluid in either branch.

In order to cooperate with said moving elements the integrated module isequipped with the support structure with said infusion, intake,post-infusion and pre-infusion branches, which are all parallel to oneanother.

The invention has important advantages.

First of all, the shape of the support element allows to keep in theirposition the various tube lengths when the module is engaged to theextracorporeal blood treatment machine.

The peculiar C-shaped section of said element enables an optimalcooperation with the elements protruding from the front wall of themachine, so as to ensure an easy and correct engagement of saidintegrate module to the machine.

Furthermore, the presence of suitable seats counter-shaped to theU-shaped tube lengths enables an optimal positioning of the circuitryaround the peristaltic pumps, thus highly reducing the possibility ofmistakes made by the operators activating the unit.

It should then be noted that the box-like shape provides a substantialprotection and covering for all the moving parts of the machine (werefer in particular to the peristaltic pumps and to the selectingelements for blocking/enabling the fluid flow in the respective tubes).

Moreover, the possibility of carrying out support element withtransparent material enables a visual access, thus allowing to verifythe correct positioning of the tube lengths with respect to theirrespective pumps, as well as the good working of the machine, thoughpreventing a direct access to said parts.

Eventually, the relative arrangement of the various pumps and tubelengths ensures an efficient and easy access to the blood treatmentelement, and enables extracorporeal blood circulation lengths that areas small as possible.

1. An integrated fluid treatment module comprising: a support elementcomprising a main body having a front wall and at least a peripheralwall projecting away from said front wall, said front wall and saidperipheral wall defining a housing compartment, said front wall beingdelimited by first and second opposite longer sides with a basicallyrectilinear development, each of said first and second opposite longersides having first and second curved portions forming a cavity facing arespective opposite longer side, said front wall being further delimitedby first and second opposite shorter sides with a basically rectilineardevelopment, at least one of said first and second opposite shortersides having a third curved portion configured between first and secondrectilinear lengths, a cavity formed by said third curved portion facingthe other of said first and second opposite shorter sides, the supportelement further comprising at least one pair of tube engagementconnectors, each of said at least one pair of tube engagement connectorsbeing placed on opposite ends of each of said first, second, and thirdcurved portions; at least one blood treatment unit engaged to thesupport element; and a fluid distribution circuitry associated with thesupport element and cooperating with the treatment unit.
 2. A moduleaccording to claim 1, wherein the fluid distribution circuitry comprisesat least a blood line having a blood withdrawal branch and a bloodreturn branch.
 3. A module according to claim 2, wherein the blood lineis secured to the support element on one of said first and secondopposite shorter sides having the curved portion.
 4. A module accordingto claim 3, wherein the blood line is secured to the support element soas to define at least one tube length arranged as a U with respect tosaid support element, the tube length being designed to cooperate with arespective pump.
 5. A module according to claim 4, wherein the U-shapedtube length extends inside the peripheral wall of the support element.6. A module according to claim 4, wherein positioning projections act onthe U-shaped tube length of the blood line to keep said U-shaped tubelength in a constant position.
 7. A module according to claim 4, whereinthe tube length of the blood line secured to the support element isdefined by the withdrawal branch.
 8. A module according to claim 1,wherein the fluid distribution circuit further comprises at least anintake line for a fresh dialysis liquid.
 9. A module according to claim8, wherein the intake line for fresh dialysis liquid is fastened to thesupport element on one of said first opposite longer sides.
 10. A moduleaccording to claim 9, wherein the intake line for fresh dialysis liquidis secured to the support element so as to define at least a tube lengtharranged as a U with respect to said support element, said tube lengthbeing designed to cooperate with a respective pump.
 11. A moduleaccording to claim 9, wherein the U-shaped tube length extends insidethe peripheral wall of the support element.
 12. A module according toclaim 8, wherein the intake line is secured to the main body on thesupport element, at least an inlet length of the intake line beingengaged into a main seat of a positioning fin and to a respectiveengagement connector, at least an outlet length of the intake line beingengaged into a main seat of the positioning fin and to a respectiveengagement connector.
 13. A module according to claim 12, wherein theinlet and outlet lengths engaged to the respective engagement connectorsare placed in rectilinear arrangement, said inlet and outlet lengthsbeing parallel to one another.
 14. A module according to claim 12,wherein the outlet length branches into an intake branch designed toconvey fluid to the blood treatment unit, and into an infusion branchdesigned to convey fluid into the blood line.
 15. A module according toclaim 14, wherein the branching of the outlet length into said infusionbranch and said intake branch is defined on an engagement connector. 16.A module according to claim 14, wherein the infusion branch is securedto an auxiliary seat and to another main seat.
 17. A module according toclaim 14, wherein the infusion branch and the intake branch, whenengaged to the support element, are placed in rectilinear arrangement,said infusion branch and said intake branch being parallel to oneanother.
 18. A module according to claim 1, wherein the fluiddistribution circuitry comprises at least an infusion line.
 19. A moduleaccording to claim 18, wherein the infusion line is secured to thesupport element on one of said first and second opposite longer sides.20. A module according to claim 19, wherein the infusion line isfastened to the support element so as to define at least a tube lengtharranged as a U with respect to said support element, said tube lengthbeing designed to cooperate, when in use, with a respective pump.
 21. Amodule according to claim 20, wherein the tube length arranged as a Uextends inside the peripheral wall of the support element.
 22. A moduleaccording to claim 18, wherein the infusion line is secured to the mainbody on the support element, at least an outlet length of the infusionline being engaged into a main seat of a positioning fin and to arespective engagement connector.
 23. A module according to claim 22,wherein the outlet length branches into a pre-infusion branch designedto convey the fluid to a withdrawal branch of the blood line, and into apost-infusion branch designed to convey the fluid to a blood returnbranch of the blood line.
 24. A module according to claim 23, whereinthe branching of the outlet length into said pre-infusion branch andsaid post-infusion branch is defined on an engagement connector.
 25. Amodule according to claim 23, wherein the pre-infusion branch is securedto an auxiliary seat and to another main seat of the positioning fin.26. A module according to claim 23, wherein the pre-infusion branch andthe post-infusion branch, when engaged to the support element, areplaced in rectilinear arrangement, said pre-infusion branch and saidpost-infusion branch being parallel to one another.
 27. A moduleaccording to claim 1, wherein the fluid distribution circuit comprisesat least a discharge line.
 28. A module according to claim 27, whereinthe discharge line conveys a waste fluid, said discharge line being issecured to the support element on one of said first and second oppositelonger sides.
 29. A module according to claim 28, wherein said dischargeline is secured to the support element so as to define at least a tubelength arranged as a U with respect to said support element, said tubelength being designed to cooperate, when in use, with a respective pump.30. A module according to claim 29, wherein the U-shaped tube lengthextends inside the peripheral wall of the support element.
 31. A moduleaccording to claim 27, wherein the discharge line is fastened to themain body on the opposite side with respect to the support element, aninlet length and an outlet length of the discharge line being engagedinto corresponding engagement connectors.
 32. A module according toclaim 1, wherein the fluid distribution circuit comprises at least anauxiliary pre-infusion line.
 33. A module according to claim 32, whereinthe auxiliary pre-infusion line is fastened to the support element onone of said first and second opposite longer sides.
 34. A moduleaccording to claim 33, wherein said pre-infusion line is secured to thesupport element so as to define at least one tube length arranged as a Uwith respect to said support element, said tube length being designed tocooperate, when in use, with a respective pump.
 35. A module accordingto claim 34, wherein the U-shaped tube length extends inside theperipheral wall of the support element.
 36. A module according to claim32, wherein the auxiliary pre-infusion line is fastened to the main bodyon the opposite side with respect to the support element, at least aninlet length and at least an outlet length of the auxiliary pre-infusionline being engaged into corresponding engagement connectors.
 37. Amodule according to claim 4, wherein said at least one U-shaped tubelength is smaller than or the same as (πR+2R), where R is the respectiveradius of curvature of the tube length.
 38. An integrated moduleaccording to claim 4, wherein the fluid distribution circuit comprisesfurther fluid lines secured to the support element, each further fluidline defining at least a tube length arranged as a U with respect tosaid support element, each tube length being designed to cooperate, whenin use, with a respective pump, the support element having a first zoneto which a portion of the blood line is fastened and at least a secondzone opposite said first zone, the further fluid lines being all securedon said second zone.
 39. A Module according to claim 38, wherein theU-shaped tube length of the blood line is longer than the tube lengthsdefined by the further fluid lines.
 40. A module according to claim 38,wherein the U-shaped tube length of the blood line has a greater radiusof curvature than the tube lengths defined by the further fluid lines.41. A module according to claim 38, wherein said second zone comprisesat least first and second half-parts placed side by side, at least atube length of a discharge line of a waste fluid being fastened to thesecond half-part.
 42. A module according to claim 38, wherein saidsecond zone comprises at least first and second half-parts placed sideby side, at least a tube length of an intake line for fresh liquid beingfastened to the first half-part.
 43. A module according to claim 38,wherein said second zone comprises at least first and second half-partsplaced side by side, at least a tube length of an infusion line beingfastened to the first half-part.
 44. A module according to claim 38,wherein said second zone comprises at least first and second half-partsplaced side by side, at least a tube length of an auxiliary pre-infusionline being fastened to the second half-part.
 45. A module according toclaim 38, wherein the first zone is partly delimited by at least one ofsaid first and second opposite shorter sides having the curved portionand by a portion of the first opposite longer side beside said at leastone of said first and second opposite shorter sides having the curvedportion.
 46. A module according to claim 38, wherein the second zone ispartly delimited by one of said first and second opposite shorter sideswithout the curved portion and by a portion of the first opposite longerside beside said at least one of said first and second opposite shortersides without the curved portion.
 47. A module according to claim 38,wherein when the module is associated to an extracorporeal bloodtreatment machine, the first zone of the support element is placed belowthe second zone of the support element.
 48. A module according to claim41, wherein when the module is associated to an extracorporeal bloodtreatment machine, the first and second half-part of the second zone ofthe support element are placed side by side.
 49. A module according toclaim 38, wherein one of said first and second opposite shorter sideswithout the curved portion has no tube length directly fastened thereto.50. A module according to claim 41, wherein the first and secondhalf-parts are specularly symmetrical with respect to a longitudinalaxis of the main body.
 51. A module according to claim 1, wherein saidtreatment unit is fastened to the main body on at least a pair ofconnectors.
 52. A module according to claim 51, characterized in thatsaid pair of connectors is placed between counter-connectors and aportion of the fluid distribution circuit.
 53. A module according toclaim 1, in which said treatment unit comprises: a housing body; atleast a semipermeable membrane operating inside the housing bodydefining a first and a second chamber; a first and a secondcounter-connector associated to the housing body and fastened torespective connectors associated to the main body, at least one of saidfirst and second counter-connector being put into fluid communicationwith the second chamber of the treatment unit and with respective firstend portions of said respective connectors; at least an access door tosaid first chamber; and at least an exit door from said first chamber.54. A module according to claim 53, wherein the fluid distributioncircuit comprises at least a discharge line for a waste fluid, saiddischarge line being in communication with a second end portion of oneof said respective connectors.
 55. A module according to claim 54,wherein the fluid distribution circuit comprises at least an intake linefor fresh dialysis liquid, said intake line being in communication withthe second end portion of one of said respective connectors.
 56. Amodule according to claim 53, in which the fluid distribution circuitcomprises at least a blood line having a blood withdrawal branch, saidblood line being in communication with the access door to the firstchamber, and at least a blood return line, said blood return line beingin communication with the exit door from the first chamber.
 57. A moduleaccording to claim 38, wherein the blood line has tubes comprising adifferent material with respect to the further fluid lines.